![]() We also show screening results for three diverse protein targets. Here, we describe the design, synthesis, and validation experiments performed for a 3.7 million-member DEL, generated using diverse skeleton architectures with varying exit vectors and derived from DOS, to achieve structural diversity beyond what is possible by varying appendages alone. Despite recent advancements in this field, most DEL syntheses are limited by the presence of sensitive DNA-based constructs. ![]() In parallel to the development of DOS, DNA-encoded libraries (DELs) have emerged as an effective, efficient screening strategy to identify protein binders. Nature Communications volume 14, Article number: 4930 ( 2023)ĭiversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. Diversity-oriented synthesis encoded by deoxyoligonucleotides
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